Authorities said it happened around 6 p.m. on Highway 30.
They said a SUV driven by 44-year-old Troy Olmstead, of Overton, collided with a van driven by 63-year-old Linda Waldon.
Waldon was pronounced dead at the scene.
Olmstead and two passengers in the SUV were transported to the Cozad hospital.
They're in stable condition.
The cause of the crash is still under investigation.