Fire crews were called to the scene a little after 10:30 a.m. Tuesday.
Once there, firefighters found 58-year-old Randy Mills at the back door of his house and pulled him outside to begin CPR.
Mills was taken to Great Plains Regional Medical Center, then flown to a Lincoln hospital. He suffered airway burns from smoke and heat in the house.
Investigators say the fire began in the basement but are not yet sure of the cause.