It happened around 8:30 p.m. at the intersection of Highway 11 and Sargent Road.
A black Toyota SUV driven by Dana Lanier, of Colorado, was eastbound on Sargent Road, and a pickup, driven by Mark Suckstrof of Burwell was southbound on Highway 11.
Officers are still working to figure out exactly what happened, but they say the pickup collided with the driver's side of the SUV.
Both drivers were taken to a local hospital, and Lanier was then transferred to Good Samaritan in Kearney.
The accident is still under investigation.